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Our areas of expertise include: Information and Communication complex multiple-system and multiple-vendor installations with the best The recent approval of an iSTAT point of care test to detect mild TBI has paved the way for future biomarker clearance and appropriate clinical use across the globe.īiomarkers consortiums point of care regulatory pathways traumatic brain injury.ICAD is the leading provider of airport integration services in the Middle With our highly expertise team we are proficient of delivering the even mostĮast. TBI biomarker research has significantly advanced in the last decade. Finally, we analyze the regulatory pathways for converting promising TBI biomarkers into approved in-vitro diagnostic tests in the United States, European Union, and Canada. This paper covers heavily investigated TBI biomarkers and emerging non-protein markers. As each geographical region regulates its data and findings, the International Initiative for Traumatic Brain Injury Research (InTBIR) was formed to facilitate data integration and dissemination across these consortia. With the global necessity of TBI biomarkers research, several major consortium multicenter observational studies with biosample collection and biomarker analysis have been created in the USA, Europe, and Canada. Significantly, the FDA has recently cleared both a bench-top assay and a rapid point-of-care assays of tandem biomarker (UCH-L1/GFAP)-based blood test to aid in the diagnosis mTBI patients. Prior research has found that biomarkers aid in the pathophysiological characterization and diagnosis of TBI. Traumatic brain injury (TBI) is a major global health issue, resulting in debilitating consequences to families, communities, and health-care systems.

13 National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, USA.

12 Fundación Universitaria Sanitas, Bogota, Colombia.

11 Department of Neurosurgery, Pecs University, Pecs, Hungary.

10 Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

9 The Hospital for Sick Children, Department of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

8 Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

7 Department of Neurology, Uniformed Service University, Bethesda, Maryland, USA.

6 Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Canada.

5 Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

4 Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.3 Department of Pediatric Critical Care, University of Miami Miller School of Medicine, Miami, Florida, USA.2 Brain Rehabilitation Research Center (BRRC), Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA.1 Program for Neurotrauma, Neuroprotoemics & Biomarker Research, Department of Emergency Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

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